Antibody-Binding Proteins and Conjugates
Cayman Chemical FosInoprIlsodIum salt 50mg
An internal standard for the quantification of cholic acid by GC- or LC-MS
Cayman Chemical ArachIdIc AcIdodIum salt 50mg
An internal standard for the quantification of tenofovir by GC- or LC-MS
Cayman Chemical LFolInIc AcIdcalcIM salt 500mg
A dual inhibitor of FAK1 (IC50s 2 0 and 80 nM for in vitro enzyme and cellular inhibition respectively) and ALK (IC50s 3 1 and 22 nM for in vitro enzyme and cellular inhibition respectively) blocks the proliferation of breast cancer cell lines in vitro or in vivo
Cayman Chemical OlsalazInsodIum salt 500mg
A cell-permeable inhibitor of PCSK9 secretion (IC50 4 8 UM) promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels
Cayman Chemical t232trIfluoroacetAT salt 50mg
A TLR7 agonist induces reporter gene activity in HEK293 cells expressing human TLR7 (EC50 7 9 nM) induces production of CXCL10 IL-12p70 IFN-Y and TNF-a in splenocytes isolated from Tlr7 wild-type mice reduces tumor volume and increases survival as well as potentiates the antitumor effects of ionizing radiation in a CT26 murine colon cancer model potentiates the antitumor effects of ionizing radiation and decreases the number of metastases in a KHT murine fibrosarcoma model
Cayman Chemical BIctegravIrsodIum salt 50mg
An ACL inhibitor (Ki 7 nM) inhibits the production of ADP in a cell-free assay and oxaloacetate production in an enzyme-coupled assay (IC50s 2.1 and 4.8 nM respectively)
Cayman Chemical RW3trIfluoroacetate salt 50mg
A metabolite of cortisol urinary levels are decreased in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma
Cayman Chemical BatbulInsodIum salt 50mg
A CXCR4 antagonist (IC50 0.91 nM) inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 4 nM) reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 UM reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model reduces the incidence of arthritis in a mouse model of collagen-induced arthritis
Cayman Chemical MaduramIcInamonIum salt 50mg
A cereblon modulator binds to cereblon (IC50 0.03 UM in a FRET assay) and induces the degradation of Ikaros and Aiolos in H929 R10-1 at 1 10 and 100 nM induces apoptosis in the same cells reduces tumor growth in an H929 R10-1 mouse xenograft model at 1 3 and 10 mg/kg
Cayman Chemical BCIPp-toluIdIn salt 500mg
An internal standard for the quantification of hydralazine by GC- or LC-MS
Cayman Chemical TInptInsodIum salt 500mg
A cell-permeable inhibitor of SCF-mediated c-kit activation completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 UM prevents SCF-mediated downstream phosphorylation of p44/p42 ERK
Cayman Chemical CefonIcIdodIum salt 500mg
An inactive major metabolite of methylphenidate intended for forensic and biological research purposes
Cayman Chemical DIdodIum salt 50mg
A natural phytochemical that has anti-cancer effects at least in part through inhibition of NF-KB and Akt signaling pathways
Cayman Chemical 1-thIoD-GlucosesodIum sa 500mg
An a-methylated analog of 2C-B-FLY and the dihydrofuran analog of DOB a potent agonist of 5-HT2A and 5-HT2C intended for forensic and research purposes